With the expansion of the terrorist group ISIS's activities in West Asia, the Khorasan branch of this group in Afghanistan has exploited the illicit drug economy to create security, economic, and political threats for the region, particularly for Iran. This research, using a descriptive-analytical method and based on the theory of defensive realism, and drawing on credible academic and online sources, examines the strategies of Iran's foreign policy in confronting the narco-terrorism of ISIS-Khorasan. Accordingly, the research answers the following question: "What strategies has the Islamic Republic of Iran adopted to reduce the threats of narco-terrorism posed by ISIS-Khorasan?" The findings indicate that these threats include the expansion of terrorism, the black economy, and political instability. By adopting a strategy of threat balancing through bilateral cooperation with Kabul, multilateral convergence in Central Asia, and strengthening relations with regional organizations such as the ECO and the Shanghai Cooperation Organization, Iran has been able to significantly reduce terrorist activities.