Given the developments in global politics and changes in strategic situations, examining Iran-EU relations in different periods requires a detailed and comprehensive analysis. These relations have been affected by numerous factors such as sanctions, Iran's nuclear program, and humanitarian issues, and have been challenged at different times. In this regard, the election of Masoud Pezekian as President of the Islamic Republic of Iran could be a sensitive and important period for these relations. His approach to foreign policy may be an opportunity to improve relations with the European Union and create a positive atmosphere for dialogue and cooperation. The aim of the present study is to examine the possibility of change in the foreign policy of the Islamic Republic of Iran towards the European Union based on John Kingdon's multiple currents theoretical model and using the content analysis method. The main question of the article is: How is the possibility of change in Iran's foreign policy towards the European Union under the Pezeshkian government based on the Kingdon model? The research findings show that in the period under discussion, using the analysis of the contents of existing texts and works, there is analytical evidence that the problem stream, the political stream, and the political stream accompanied the opening of a window of opportunity for change in the foreign policy of the Islamic Republic of Iran. However, despite the existing opportunities, serious obstacles have also cast a heavy shadow on the relations between the two sides.